![]() Migraine has been considered a disturbance in the brain of the subcortical aminergic sensory modulatory systems, in addition to hypothalamic, thalamic and brainstem structures. ![]() Unfortunately, whether migraine is associated with increased risk of narcolepsy in children has not been explored in a large-scale longitudinal study. Furthermore, as almost one-third of patients become symptomatic before reaching the age of 15, there is an increasing level of attention given on the development of narcolepsy early in life. These studies adopted case-control cross-sectional study designs with relatively small sample sizes, which could not allow us to firmly establish a causal relationship between migraine and narcolepsy, or suggest a mechanism that could explain such relationship. The association between migraine and narcolepsy has been evaluated in several hospital-based studies and still remains controversial. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Ĭompeting interests: The authors have declared that no competing interests exist. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ĭata Availability: All relevant data are within the paper.įunding: This study is supported in part by Taiwan Ministry of Health and Welfare Clinical Trial Center (MOHW106-TDU-B-212-113004), Bureau of Health Promotion, Department of Health, Taiwan (DOH99-HP-1205), Tseng-Lien Lin Foundation, Taichung, Taiwan, Taiwan Brain Disease Foundation, Taipei, Taiwan, and Katsuzo and Kiyo Aoshima Memorial Funds, Japan. Received: Accepted: NovemPublished: December 7, 2017Ĭopyright: © 2017 Yang et al. PLoS ONE 12(12):Įditor: Andrea Romigi, University of Rome Tor Vergata, ITALY Citation: Yang C-P, Hsieh M-L, Chiang J-H, Chang H-Y, Hsieh VC-R (2017) Migraine and risk of narcolepsy in children: A nationwide longitudinal study.
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